In 2006, Caleb saw action in 10 games, mostly on special teams. He recorded two tackles for the season. In 2007, he recorded a tackle on special teams against North Texas and saw time at wide receiver against the Mean Green before a season-ending injury. He received an injury hardship and had his sophomore season restored for 2008. With wide receivers Juaquin Iglesias and Manuel Johnson graduated and in the NFL, Caleb earned a starting spot in his junior year of 2009. He immediately contributed with big numbers including 7 catches for 139 yards in a game against Baylor. Caleb emerged in 2009 leading the Sooners in receptions and receiving yards through the first half of the season.