Hematologic disease

Myeloid

• Hemoglobinopathies
• * Sickle cell disease
• * Thalassemia
• * Methemoglobinemia
• Anemias
• * Iron-deficiency anemia
• * Megaloblastic anemia
• ** Vitamin B₁₂ deficiency
• *** Pernicious anemia
• ** Folate deficiency
• * Hemolytic anemias
• ** Genetic disorders of RBC membrane
• *** Hereditary spherocytosis
• *** Hereditary elliptocytosis
• *** Congenital dyserythropoietic anemia
• ** Genetic disorders of RBC metabolism
• *** Glucose-6-phosphate dehydrogenase deficiency
• *** Pyruvate kinase deficiency
• ** Immune mediated hemolytic anemia
• *** Autoimmune hemolytic anemia
• **** Warm antibody autoimmune hemolytic anemia
• ***** Idiopathic
• ***** Systemic lupus erythematosus
• ***** Evans syndrome
• **** Cold autoimmune hemolytic anemia
• ***** Cold agglutinin disease
• ***** Paroxysmal cold hemoglobinuria
• ***** Infectious mononucleosis
• *** Alloimmune hemolytic anemia
• **** Hemolytic disease of the newborn
• ***** Rh disease
• ***** ABO hemolytic disease of the newborn
• ***** Anti-Kell hemolytic disease of the newborn
• ***** Rhesus c hemolytic disease of the newborn
• ***** Rhesus E hemolytic disease of the newborn
• ***** Other blood group incompatibility
• *** Drug induced immune mediated hemolytic anemia
• **** Penicillin
• **** Methyldopa
• ** Hemoglobinopathies
• ** Paroxysmal nocturnal hemoglobinuria
• ** Direct physical damage to RBCs
• *** Microangiopathic hemolytic anemia
• *** Secondary to artificial heart valve
• * Aplastic anemia
• ** Fanconi anemia
• ** Diamond–Blackfan anemia
• ** Acquired pure red cell aplasia
• Decreased numbers of cells
• * Myelodysplastic syndrome
• * Myelofibrosis
• * Neutropenia
• * Agranulocytosis
• * Glanzmann's thrombasthenia
• * Thrombocytopenia
• ** Idiopathic thrombocytopenic purpura
• ** Thrombotic thrombocytopenic purpura
• ** Heparin-induced thrombocytopenia
• Myeloproliferative disorders
• * Polycythemia vera
• * Erythrocytosis
• * Leukocytosis
• * Thrombocytosis
• * Myeloproliferative disorder
• * Transient myeloproliferative disease
• Coagulopathies
• * Thrombocytosis
• * Recurrent thrombosis
• * Disseminated intravascular coagulation
• * Disorders of clotting proteins
• ** Hemophilia
• *** Hemophilia A
• *** Hemophilia B
• *** Hemophilia C
• ** Von Willebrand disease
• ** Disseminated intravascular coagulation
• ** Protein S deficiency
• ** Antiphospholipid syndrome
• * Disorders of platelets
• ** Thrombocytopenia
• ** Glanzmann's thrombasthenia
• ** Wiskott–Aldrich syndrome

  Hematological malignancies

• Hematological malignancies
• * Lymphomas
• ** Hodgkin's disease
• ** Non-Hodgkin's lymphoma
• *** Burkitt's lymphoma
• *** Anaplastic large cell lymphoma
• *** Splenic marginal zone lymphoma
• *** Hepatosplenic T-cell lymphoma
• *** Angioimmunoblastic T-cell lymphoma
• * Myelomas
• ** Multiple myeloma
• ** Waldenström macroglobulinemia
• ** Plasmacytoma
• * Leukemias increased WBC
• ** Acute lymphocytic leukemia
• ** Chronic lymphocytic leukemia
• ** Acute myelogenous leukemia
• ** Acute megakaryoblastic leukemia, a sub-type of acute myelogenous leukemia
• ** Chronic Idiopathic Myelofibrosis
• ** Chronic myelogenous leukemia
• ** T-cell prolymphocytic leukemia
• ** B-cell prolymphocytic leukemia
• ** Chronic neutrophilic leukemia
• ** Hairy cell leukemia
• ** T-cell large granular lymphocyte leukemia
• ** Aggressive NK-cell leukemia

  Miscellaneous

• Hemochromatosis
• Asplenia
• Hypersplenism
• * Gaucher's disease
• Monoclonal gammopathy of undetermined significance
• Hemophagocytic lymphohistiocytosis
• Tempi syndrome

  Hematological changes secondary to non-hematological disorders

• Anemia of chronic disease
• Infectious mononucleosis
• AIDS
• Malaria
• Leishmaniasis