Black Reel Award for Outstanding Lead Performance, Comedy Series

This article lists the winners and nominees for the Black Reel Award for Outstanding Lead Performance in a Comedy Series. The award recognizes an actor or actress who delivers an outstanding performance in a leading role of a comedy television series within the given eligible period.
The award was first presented at the 23rd Annual Black Reel Awards as a result of a merger between the Outstanding Actor and Outstanding Actress awards into a single gender-neutral award, with a total of ten nominees being selected. Quinta Brunson is the inaugural winner for her performance in the second season of Abbott Elementary, for which she also won a Primetime Emmy Award.

Multiple nominations and wins

;2 wins

;3 nominations

;2 nominations