Bioinformatics Resource Centers

The Bioinformatics Resource Centers are a group of five Internet-based research centers established in 2004 and funded by NIAID The BRCs were formed in response to the threats posed by emerging and re-emerging pathogens, particularly Centers for Disease Control and Prevention Category A, B, and C pathogens, and their potential use in bioterrorism. The intention of NIAID in funding these bioinformatics centers is to assist researchers involved in the experimental characterization of such pathogens and the formation of drugs, vaccines, or diagnostic tools to combat them.
The main goals of the BRCs are as follows:
1) To create comprehensive databases of reliable, up-to-date bioinformatic data related to the pathogens of interest;
2) To provide researchers with easy access to this data through Internet-based search and data retrieval user interfaces;
3) To provide researchers with relevant, state-of-the art computational tools for bioinformatic analysis of these data.
Currently there are two BRC contracts awarded, one for bacteria and viruses, and the other for vectors, Eukaryotic protozoan and fungal pathogens and host response to pathogen infections.

Name	Acrono name	Contributing organization	Organisms covered	Example organisms
Eukaryotic Pathogen, Vector and Host Informatics Resources	VEuPathDB	University of Pennsylvania University of Notre Dame University of Georgia Imperial College of London EBI-ENSEMBL	All relevant pathogenic protozoa, fungi, vectors of pathogens and selected host organisms. In addition, important non-pathogenic organisms are included for phylogenetic inferences.	Crithidia Cryptosporidium Encephalitozoon Entamoeba Enterocytozoon Giardia Leishmania Neospora Plasmodium Theileria Toxoplasma Trichomonas Trypanosoma Anopheles gambiae Anopheles species Aedes aegypti Biomphalaria glabrata Culex quinquefasciatus Glossina species Ixodes scapularis Lutzomyia longipalpis Musca domestica Pediculus humanus Phlebotomus papatasi
Bacterial and Viral Bioinformatics Resource Center	BV-BRC	J. Craig Venter Institute University of Chicago	All pathogenic bacteria and viruses	Influenza Virus Arenaviridae Bunyaviridae Filoviridae Flaviviridae Poxviridae Caliciviridae Togaviridae Hepatitis A virus Coronaviridae Paramyxoviridae Lyssavirus Hepatitis E Herpesviridae Reoviridae Bacillus Bartonella Borrelia Brucella Burkholderia Campylobacter Chlamydophila Clostridium Coxiella Ehrlichia Escherichia Francisella Helicobacter Listeria Mycobacterium Rickettsia Salmonella Shigella Staphylococcus Vibrio Yersinia Other Bacteria