William Gaines (disambiguation)
William Gaines was an American publisher, notably of Mad magazine.
William Gaines may also refer to:
Sportsmen
- Bill Gaines (basketball), American guard for San Diego Rockets
- Bill Gaines (sprinter), American 60 yard winner at 1968 USA [Indoor Track and Field Championships]
- William Gaines (American football), NFL defensive tackle
Others
- William Gaines (minister and community leader), American freed slave during Reconstruction Era in Georgia
- William E. Gaines, American congressman from Virginia
- William Gaines (professor), American Pulitzer Prize-winning investigative reporter