| Year | Song | Artist | Nominees |
| 2000 | A Puro Dolor | Son by Four | |
| 2005 | La Tortura | Shakira feat. Alejandro Sanz | Daddy Yankee-Lo Que Pasó, Pasó
Juanes-La Camisa Negra
Conjunto Primavera-Hoy Como Ayer |
| 2011 | Waka Waka (This Time for Africa) | Shakira & Freshly Ground | Shakira-Loca
Shakira-Gypsy (Shakira)
Pitbull-Bon, Bon
Enrique Iglesias feat. Juan Luis Guerra-Cuando Me Enamoro |
| 2012 | Danza Kuduro | Don Omar feat. Lucenzo | Romeo Santos feat. Usher-Promise
Pitbull-Bon, Bon
Don Omar-Taboo
Prince Royce-Corazón sin cara |
| 2013 | Ai Se Eu Te Pego | Michel Teló | Juan Magan feat. Pitbull and El Cata-Bailando Por El Mundo
Don Omar feat. Natti Natasha-Dutty Love
Don Omar-Hasta Que Salga el Sol
Wisin y Yandel feat. Chris Brown and T-Pain-Algo Me Gusta de Ti |
| 2014 | Vivir Mi Vida | Marc Anthony | Daddy Yankee-Limbo
Loco
Enrique Iglesias feat. Romeo Santos-Loco
Prince Royce-Darte un Beso
Romeo Santos-Propuesta Indecente |
| 2015 | Bailando | Enrique Iglesias feat. Descemer Bueno and Gente de Zona | J Balvin feat. Farruko-6 AM
Romeo Santos-Eres Mía
Romeo Santos feat. Drake-Odio
Romeo Santos-Propuesta Indecente |
| 2016 | El Perdón | Nicky Jam and Enrique Iglesias | J Balvin-Ginza
Ariel Camacho and Los Plebes del Rancho-Te Metiste
Maluma-Borro Cassette
Romeo Santos-Propuesta Indecente |
| 2017 | Hasta El Amanecer | Nicky Jam |
|
| 2018 | Despacito | Luis Fonsi and Daddy Yankee featuring Justin Bieber | "Mi Gente" - J Balvin and Willy William featuring Beyonce "Mayores" - Becky G featuring Bad Bunny "Felices Los 4" - Maluma "Escapate Conmigo" - Wisin featuring Ozuna |
| 2019 | Te Boté | Casper Magico, Nio Garcia, Darell, Nicky Jam, Bad Bunny and Ozuna | "Mia" - Bad Bunny featuring Drake "Dura" - Daddy Yankee "Taki Taki" - DJ Snake featuring Selena Gomez, Ozuna and Cardi B "X" - Nicky Jam and Bad Bunny |
| 2020 | Con Calma | Daddy Yankee featuring Snow | "China" - Anuel AA, Daddy Yankee, Karol G, Ozuna and J Balvin "Callaíta" - Bad Bunny and Tainy "No Me Conoce" - Jhay Cortez, J Balvin and Bad Bunny "Otro Trago" - Sech featuring Darell, Nicky Jam, Ozuna and Anuel AA |
| 2021 | Dákiti | Bad Bunny and Jhay Cortez | "Yo Perreo Sola" - Bad Bunny "Ritmo (Bad Boys for Life)" - Black Eyed Peas and J Balvin "Hawái" - Maluma and The Weeknd "Caramelo" - Ozuna, Karol G and Myke Towers |
| 2022 | Telepatía | Kali Uchis | "Todo de Ti" - Rauw Alejandro "Volví" - Aventura and Bad Bunny "Yonaguni" - Bad Bunny "Pepas" - Farruko |
| 2023 | Ella Baila Sola | Eslabon Armado and Peso Pluma | "Bebe Dame" - Fuerza Regida and Grupo Frontera "Un x100to" - Grupo Frontera and Bad Bunny "TQG" - Karol G and Shakira "La Bebé" - Yng Lvcas and Peso Pluma |
| 2024 | Gata Only | FloyyMenor and Cris MJ | "Monaco" - Bad Bunny "Perro Negro" - Bad Bunny and Feid "Qlona" - Karol G and Peso Pluma "La Diabla" - Xavi |