Big Six
- 2-10-2
- BIG6 European Football League
- Baltimore and Ohio class S
- Big 12
- Big 6 (album)
- Big 6 Brass Band
- Big 6 Hockey League
- Big Eight (disambiguation)
- Big Eight Conference
- Big Five (disambiguation)
- Big Four (disambiguation)
- Big Hero 6 (film)
- Big One (disambiguation)
- Big Seven (disambiguation)
- Big Six (Premier League)
- Big Six (activists)
- Big Six (endurance racing)
- Big Six (ice hockey)
- Big Six (law firms)
- Big Six (song)
- Big Six Junior College Conference
- Big Six auditors
- Big Six cricket dispute of 1912
- Big Six energy suppliers
- Big Six wheel
- Big Ten (disambiguation)
- Big Three (disambiguation)
- Big Two (disambiguation)
- Big six in the romantic literature of England
- Christy Mathewson
- Dizzy (series)
- International Typographical Union
- Jason Estrada
- John "Big Train" Moody
- Mercedes-Benz M186 engine
- Morris Big Six
- Northwest Conference (1908–1925)
- Pac-12 Conference
- Shay locomotive
- Supreme War Council (Japan)
- The Big Six
- The Big Six (Ghana)
- Tokyo Big6 Baseball League