Bighead
- Big head mode
- Big-head schizothoracin
- Bighead (graphic novel)
- Bighead (record producer)
- Bighead River
- Bighead carp
- Bighead catshark
- Bighead goby
- Bighead pupfish
- Bighead sculpin
- Bighead spurdog
- Bigheads
- Centaurea macrocephala
- Edward Lee (writer)
- Girl Interrupted (album)
- Grosse Tête, Louisiana
- Hydrophis annandalei
- Jack Bighead
- Juncus megacephalus
- List of Rocko's Modern Life characters
- Megalocephalus
- Silicon Valley (TV series)
- Space Ghost's Musical Bar-B-Que
- The Ambiguously Gay Duo
- Wu Kwok Hung