Big Bill
Big Bill is a nickname that may refer to:
- Bill Abstein, American Major League Baseball and amateur soccer player
- Bill Bachrach, American swim and water polo coach
- Bill Bagwell, American Major League Baseball player
- Big Bill Bissonnette, American jazz trombonist and producer
- Big Bill Broonzy, American blues singer and guitarist
- William Stephen Devery, New York City Police superintendent and first police chief, later co-owner of the New York Yankees baseball team
- Bill Dwyer , prohibition gangster and bootlegger
- Big Bill Edwards, American college football player
- Bill France Sr., American racing driver, co-founder, Chairman and CEO of NASCAR
- Bill Gatewood, American Negro league baseball player and manager
- Bill Haywood, a prominent figure of the American labor movement
- William H. Hodgins, New York City police captain
- Bill Hollenback, American college football Hall-of-Fame player and coach
- Bill James , Major League Baseball pitcher
- Bill Kemmer, American Major League Baseball player
- Bill Lee , Major League Baseball pitcher
- William McKinley, 25th President of the United States
- Big Bill Morganfield, American blues singer and guitarist
- Big Bill , American professional wrestler
- Big Bill Neidjie, last surviving speaker of the Gagudju language
- Big Bill Smith, American Negro league baseball player and manager
- Bill Speakman, British Army soldier awarded the Victoria Cross
- William Howard Taft, 27th president of the United States
- William Hale Thompson, mayor of Chicago
- Bill Tilden, American tennis player
- Bill Verna, Australian professional wrestler
- Bill Voiselle, Major League Baseball pitcher
- William Watson , first African-American to win the national decathlon championship
- Bill Werbeniuk, Canadian snooker player