Berlinia grandiflora is a small to medium sized tree that ranges from 2–20 m tall but can grow up to 30 m. Leaves are paripinnately compound arranged in 3–4pairs of leaflets per pinnae, the petiole is 20-42 mm long and petiolules is 5–9 mm long; terminal leaflets are 7–22 cm long and 3.0–11.5 cm wide, the abaxial surface is glabrous to sparsely pubescent, leaf-blade is oblong to obovate in outline. Inflorescence is a branched panicle, it has scented green or white colored flowers, commonly with a single petal that is white and 3.5–6.5 cm long, the bracteoles tend to be between 23–32 mm long and 11–20 mm wide; has up to 10 stamens. Fruit is a flattened brown pod.
Bark extracts are used as part of a purgative regimen in some communities of the Democratic republic of the Congo and leaves are part of a decoction to treat intestinal ailments. Wood is used in carpentry work.