BD1018
BD1018 or -2-octahydropyrrolopyrazine is a selective sigma receptor ligand, with a reported binding affinity of Ki = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor. Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist.
Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice.