April 22 (Eastern Orthodox liturgics)
April 21 - Eastern Orthodox liturgical calendar - April 23
All fixed commemorations below are observed on May 5 by Eastern Orthodox Churches on the Old Calendar.
For April 22nd, Orthodox Churches on the Old Calendar commemorate the Saints listed on April 9.
Saints
Holy Apostle Nathaniel of the Twelve- Apostles Apelles, Luke, and Clement, of the Seventy
- Martyr Leonides of Alexandria, Bishop
- Martyr Nearchus, by fire Venerable Theodore the Sykeote, Bishop of Anastasiopolis in Galatia
- Saint Vitalis of Gaza, monk of the monastery of Abba Seridus at Gaza
Pre-Schism Western saints
- Hieromartyr Soter, Pope of Rome
- Martyrs Epipodius of Lyons, by beheading
- Saint Gaius, born in Dalmatia, became Pope of Rome, martyred with members of his family
- Saint Agapitus I, Pope of Rome
- Saint Leo of Sens, Bishop of Sens in France for twenty-three years
- The Two Brothers Arwald, sons of Arwald, the last Jutish King of the Isle of Wight, put to death by soldiers of King Ceadwalla, then a pagan, on the day after their baptism
- Saint Opportuna of Montreuil, sister of St Chrodegang, Bishop of Séez, Abbess at the convent of Monteuil
- Saint Senorina, a Galician abbess who served as the abbess of the Benedictine convent of St John of Venaria
Post-Schism Orthodox saints
- Saint Ananias of Malles, first monk, renovator and Abbot of the Holy Monastery of Panagia Exakousti in the village of Malles in Ierapetra, Crete
- Saint Ekaterina, fool-for-Christ, of the Holy Dormition Pukhtitsa Convent in Estonia
New martyrs and confessors
- New Hieromartyr Eustathius Malahovsky, Priest
- New Hieromartyr Platon of Banja Luka, Bishop of Banja Luka
- Martyr Demetrius Vlasenkov
Other commemorations
- Translation of the relics of St. Vsevolod, Prince and Wonderworker of Pskov
- Repose of Blessed fool-for-Christ Athanasius Andreyevich Saiko of Orel