Applications of CRSIPR/Cas9 in Cancer Research
Applications of CRSIPR/Cas9 in Cancer Research is a scholarly work, published in 2018 in ''Journal of Cancer Science and Research''. The main subjects of the publication include medicine, cancer, CRISPR, ageing, and cell potency. The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies.Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations.It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer.The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models.Here authors will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.