Anne Weying first appeared in The Amazing Spider-Man #375, and was created by writer David Michelinie and artist Mark Bagley. She-Venom first made a cameo appearance in #2 and her first full appearance was in Venom: Sinner Takes All #3, and was created by writer Larry Hama and artist Greg Luzniak. She is the first character who goes by the She-Venom identity before Patricia Robertson.
In Anne Weying's first appearance, she is a brunette with glasses. In later appearances, she loses the glasses and goes blonde. Anne was a successful lawyer, and Eddie Brock's ex-wife. Weying assisted Spider-Man by sharing some of Eddie's history. She later followed Spider-Man to the amusement park where Venom had Peter Parker's parents. She confronted her insane ex-husband, and managed to convince Eddie to give up this vendetta. Later, Sin-Eater shot Ann to which the Venom symbiote temporarily bonded with her to save her life. She-Venom then lashed out against the men who had hurt her with such violence that Eddie became afraid for her and compelled the Venom symbiote back. Anne retched upon seeing the pile of bodies she had left behind; claiming that the Venom symbiote made her kill, but Eddie told her that the Venom symbiote wouldn't force its host to do something they did not want to. Weying is later incarcerated by the police on a false charge in order to trap Venom. Anne used her one phone call to warn Eddie and to promise not to come. Eddie agreed not to rescue her himself, and instead sent the Venom symbiote through the phone lines to her. After the Venom symbiote bonded with her, She-Venom was able to break herself out of prison, heading to the amusement park where she and Spider-Man had confronted Venom, only to intercept a raid on a gang of drug dealers. During the fight, Eddie was badly injured by a flamethrower, prompting Anne to release the Venom symbiote to heal but left Eddie in disgust at the dependence on the Venom symbiote. Still reeling from the experience of bonding with the Venom symbiote months earlier and unable to deal with Eddie's return into her life, coupled with Brock's transformation directly in front of her as Venom ran off to kill Spider-Man, sent her over the edge. Weying commits suicide after spotting Spider-Man webslinging in an older black costume at a time when the regular red and blue suit had been stolen. She leapt from her high rise apartment to her death. Her death is later confirmed when her tombstone is shown. In a flashback, it is revealed that she got pregnant with Eddie's child after bonding to Venom. After giving birth to a boy named Dylan who she left in the care of under the promise that she would return eventually, but committed suicide instead to which Carl raised Dylan. Its later established that Anne was apparently already pregnant with Eddie's child when she last bonded with the Venom symbiote, with the codex that was left inside Anne by Venom being absorbed by the fetus that would be Dylan.
During the Secret Wars storyline taking place in King James' England, Anne Weying is a "village beauty" who is brainwashed by printer's apprentice Edwin Brocc into loving with powers and potions supplied by the Enchantress. Anne is freed after Brock is slain by Angela.
Anne Weying appears in the 2018 film Venom, portrayed by Michelle Williams. She is the fiancée of Eddie Brock and a lawyer for the Life Foundation. Anne is fired by her firm after Eddie reads her confidential information email to confront Carlton Drake regarding said information, breaking up with Brock. Six months later, Anne has become a district attorney. She has developed a relationship with Dr. Dan Lewis but reluctantly helps Eddie upon learning about the Venom symbiote in the process. Anne is later approached by Venom as a host and kills Roland Treece and his men while saving Brock. Anne kisses Eddie, transferring the Venom symbiote back to Brock. When Riot overpowers Venom, Anne uses the Life Foundation's high frequency volume controls on a loudspeaker which results in both hosts being separated from their respective symbiotes. In the end, Anne is in good terms with Eddie as both share their experiences with the Venom symbiote.
Anne Weying is set to return in the upcoming , with Williams reprising her role, her role in the sequel however will be much smaller than the first.
She-Venom appears as a playable character in Spider-Man Unlimited.
Ann Weying and Robbie Robertson are both abducted by terrorists in the 1998 novel .