Androsterone glucuronide

Androsterone glucuronide is a major circulating and urinary metabolite of testosterone and dihydrotestosterone. It accounts for 93% of total androgen glucuronides in women. ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. It is a marker of acne in women while androstanediol glucuronide is a marker of hirsutism in women.

Relevance in women's health

Quantification of ADT-G and 3α-diol-G levels in Serum (blood) is an effective means of assessing androgen content in blood and androgenic activity in women. Androsterone glucuronide content can be estimated using Liquid chromatography–mass spectrometry. If an unusual level of ADT-G is observed in the blood, proper treatment plans can be developed in order to treat related symptoms.
Elevated levels of androsterone glucuronide in the blood have been observed in adult females who present with inflammatory acne. The introduction of therapeutic antiandrogen treatment and the use of an oral Contraceptive by women who are affected with androsterone related acne can decrease the amount of inflammatory acne present.