List of airlines of the United States

This is a list of airlines that have an air operator's certificate issued by the Federal Aviation Administration of the United States.
Note: Destinations in bold indicate primary hubs, those in italic indicate secondary hubs, and those with regular font indicate focus cities. For legacy carriers American, Delta, and United, the most strategic/well connected hubs are shown as primary hubs.

Passenger airlines

Mainline

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Alaska Air Group		AS	ASA	ALASKA	Seattle/Tacoma Daniel K. Inouye International Airport Anchorage Los Angeles Portland (OR) San Diego San Francisco	1932	Founded as McGee Airways and commenced operations in 1944 as Alaska Airlines. Hawaiian Airlines merged into Alaska Air Group in 2024, though the two airlines remain as separately branded.
Allegiant Air		G4	AAY	ALLEGIANT	Las Vegas Allentown Appleton Asheville Bellingham Cincinnati Destin/Fort Walton Beach Des Moines Flint Fort Lauderdale Grand Rapids Indianapolis Knoxville Nashville Orlando/Sanford Phoenix/Mesa Pittsburgh Provo Punta Gorda Sarasota Savannah St. Petersburg/Clearwater	1997	Founded as WestJet Express and began operations in 1998 as Allegiant Air.
American Airlines		AA	AAL	AMERICAN	Charlotte Chicago–O'Hare Dallas/Fort Worth Miami Philadelphia Phoenix–Sky Harbor Los Angeles New York–JFK New York–LaGuardia Washington–National	1926	Founded as American Airways and commenced operations in 1936 as American Air Lines Largest airline in the world based on airline company revenue, and scheduled passenger miles flown in 2025.
Avelo Airlines		XP	VXP	AVELO	New Haven Charlotte/Concord Lakeland Raleigh/Durham Wilmington (DE) Wilmington (NC)	1987	Founded as Casino Express Airlines and commenced operations in 1989. Started scheduled service in Burbank, CA, April 28, 2021.
Breeze Airways		MX	MXY	MOXY	Charleston (SC) Akron/Canton Fort Myers Hartford New Orleans Norfolk Orlando Providence Provo Raleigh/Durham Tampa Vero Beach	2018	Founded as Moxy Airways, but was renamed due to trademark issues.
Delta Air Lines		DL	DAL	DELTA	Atlanta Detroit Minneapolis/St. Paul New York–JFK Salt Lake City Boston Los Angeles New York–LaGuardia Seattle/Tacoma	1924	Founded as Huff Daland Dusters and commenced operations in 1929 as Delta Air Service.
Frontier Airlines		F9	FFT		Denver Atlanta Chicago–O'Hare Cincinnati Cleveland Las Vegas Miami Orlando Philadelphia	1994
JetBlue		B6	JBU	JETBLUE	New York–JFK Boston Los Angeles Fort Lauderdale Orlando	1998	Founded as New Air and commenced operations in 2000 as JetBlue Airways.
Southwest Airlines		WN	SWA	SOUTHWEST	Dallas–Love Atlanta Baltimore Chicago–Midway Denver Houston–Hobby Las Vegas Los Angeles Oakland Orlando Phoenix–Sky Harbor Nashville	1967	Founded as Air Southwest and commenced operations in 1971 as Southwest Airlines; largest airline in the world based on number of passengers served per year.
Spirit Airlines		NK	NKS	SPIRIT WINGS	Fort Lauderdale Atlantic City Atlanta Detroit Las Vegas Chicago–O'Hare Dallas/Fort Worth Baltimore Orlando Houston–Intercontinental	1980	Founded as Charter One.
		SY	SCX	SUN COUNTRY	Minneapolis/St. Paul Dallas/Fort Worth Las Vegas	1982	Commenced operations in 1983. Operates some Amazon Air cargo flights.
United Airlines		UA	UAL	UNITED	Chicago–O'Hare Denver Newark San Francisco Washington–Dulles Guam Los Angeles	1926	Founded as Varney Air Lines and commenced operations in 1931 as United Air Lines.

State-run airlines

Airline	Image	IATA	ICAO	Callsign	Primary hubs, secondary hubs	Founded	Notes
Comco						2002
Janet			WWW	JANET	Las Vegas	1972
Justice Prisoner and Alien Transportation System			JUD	JUSTICE	Oklahoma City	1980	Commenced operations in 1995.