Alprenolol


Alprenolol, or alfeprol, alpheprol, and alprenololum, is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.

Pharmacology

Pharmacokinetics

The brain-to-blood ratio of alprenolol in humans has been found to be 16:1. For comparison, the brain-to-blood ratio of the highly lipophilic propranolol was 15:1 to 26:1 and of the hydrophilic atenolol was 0.2:1.