1960–61 Alpha Ethniki
The 1960–61 Alpha Ethniki was the 25th season of the highest football league of Greece. The season began on 17 September 1960 and ended on 2 July 1961 with the play-off match. Panathinaikos won their second consecutive and fifth Greek title.
The point system was: Win: 3 points - Draw: 2 points - Loss: 1 point.
Teams
| Promoted from 1960 Beta Ethniki | Relegated from 1959–60 Alpha Ethniki |
| Atromitos Piraeus Fostiras Thermaikos | Pankorinthiakos Megas Alexandros Katerinis AE Nikaia |
League table
Top scorers
| Rank | Player | Club | Goals |
| 1 |  |oldAttendancesPanathinaikos drew the highest average home attendance in the 1960–61 Alpha Ethniki. |