Aleph-7
Aleph-7, or ALEPH-7, also known as 4-propylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is one of the Aleph series of compounds.
In his book PiHKAL, Alexander Shulgin lists Aleph-7's dose as 4 to 7mg orally and its duration as 15 to 30hours. The effects of Aleph-7 have been reported to include strangeness, slight visual changes, intense but difficult to describe altered states of consciousness, everything feeling "preprogrammed", emotional changes, negative reactions, unwillingness to take the drug again, relaxation, and paresthesia, among others. It was said to produce a "Beth state", defined as a state of uncaring, anhedonia, and emotionlesssness. Many other drugs are also said to have a touch of such a state, but Aleph-7 to have more of it than most.
It is a potent agonist of the serotonin 5-HT2A receptor, with an of 2.2 to 7.6nM and an of 116 to 189%. The drug is also a weak monoamine oxidase inhibitor, specifically a reversible inhibitor of MAO-A, with an of 2.4μM. The chemical synthesis of Aleph-7 has been described.
Aleph-7 was first described in the scientific literature by Shulgin in 1981. Subsequently, it was described in greater detail by Shulgin PiHKAL in 1991. The drug was encountered as a novel designer drug in Europe in 2005. It is a controlled substance in Canada under phenethylamine blanket-ban language.