The southern terminus of SR 199 is located at its intersection with SR81 near Tuskegee. From this point, the route travels in a northwesterly direction, where it passes under I-85, without an interchange, towards Chehaw where it turns to the west before resuming its northwesterly track just west of the city limits. It continues in this direction through to just south of Woodland where it turns to the northen route to its northern terminus at SR 14. North of its terminus, it continues as Macon CountyRoad 35.