SR 185 begins at its intersection with US 31 south of Greenville. From this point, the route continues in a northerly track where it intersects SR 10 just west of the Greenville central business district. SR 185 continues north through the city and intersects both SR 245 and I-65 at Exit 130 prior to leaving the city limits. From this point, the route continues in its northerly track and intersects SR 263en route to Fort Deposit. SR 185 then reorients in an easterly direction at Fort Deposit and continues its course where it again intersects I-65 prior to reaching its northern terminus at US 31.