1921 Columbus Panhandles season
The 1921 Columbus Panhandles season was their second in the newly formed American Professional Football Association. The team played all but one of their nine league games on the road, finishing the year with a record of 1 win and 8 losses, seventeenth in the league.
During the 1921 season, Columbus was outscored by its opponents by a margin of better than 4 to 1.