Afton
- Affton, Missouri
- Afton (town), New York
- Afton (village), New York
- Afton Center, Illinois
- Afton Chemical
- Afton Cooper
- Afton Run
- Afton Township, Brookings County, South Dakota
- Afton Township, DeKalb County, Illinois
- Afton Township, North Dakota
- Afton Township, Sanborn County, South Dakota
- Afton Township, Sedgwick County, Kansas
- Afton Williamson
- Afton, Charlevoix County, Michigan
- Afton, Glenn County, California
- Afton, Iowa
- Afton, Isle of Wight
- Afton, Michigan
- Afton, Minnesota
- Afton, Nevada
- Afton, New Jersey
- Afton, Nova Scotia
- Afton, Ohio
- Afton, Oklahoma
- Afton, Prince Edward Island
- Afton, San Bernardino County, California
- Afton, Tennessee
- Afton, Texas
- Afton, Virginia
- Afton, West Virginia
- Afton, Wisconsin
- Afton, Wyoming
- Five Nights at Freddy's
- Glen Afton
- List of places in Georgia (U.S. state) (A–D)
- River Afton