| Title | Originally aired | Description |
| Art Prison | 2018 | Aired on July 29, 2018. |
| Bad Guys | 2016 | Aired on December 4, 2016. |
| Captain Sturdy: The Originals | 2003 | Produced by Renegade Animation. Sequel/rework to a Cartoon Network 2001 pilot originally aimed at children. Rejected by Adult Swim. |
| Cheyenne Cinnamon and the Fantabulous Unicorn of Sugar Town Candy Fudge | 2010 | Features the voices of Neko Case and MC Chris. The pilot aired on March 29, 2010, as the winner of an online popularity contest sponsored by Burger King. It was not picked up as a series. |
| Chuck Deuce | 2018 | Aired on May 13, 2018. |
| Di Bibl | 2019 | Aired on April 22, 2019. |
| Duckworth | 2011 | Live-action pilot created by Dave Willis and Matt Harrigan starring Matt Berry, Dana Snyder, Jason Mantzoukas, and Bill Raymond. Pilot aired in Adult Swim's "DVR Theater" on January 18, 2011. |
| Eggland | 2022 | Produced in 2022. Pilot uploaded to the Adult Swim's YouTube channel on August 3, 2024. |
| The Finkel Files | 2002 | Produced by FlickerLab and aired in 2002; rejected by Cartoon Network. |
| Filthy Sexy Teen$ | 2013 | Live action pilot created by Paul Scheer, Jonathan Stern, and Curtis Gwinn. Produced by Abominable Pictures and Scheer's company 2nd Man On The Moon. Premiered on October 10, 2013. Later picked up by online service Fullscreen. |
| Gigglefudge, USA! | 2016 | Aired April 11, 2016. |
| The Groovenians | 2002 | Created by Kenny Scharf and produced by Cartoon Network Studios. Rejected due to extremely negative reviews from critics and audiences. |
| The Hindenburg Explodes! | 2016 | Live-action comedy centering on the Hindenburg disaster. Created by Rob Corddry, Josh Perilo, and Jonathan Stern. Aired December 2, 2016. |
| Hunky Boys Go Ding-Dong | 2018 | Created by Todd Rohal and produced by PFFR. Aired on December 4, 2018. |
| Korgoth of Barbaria | 2006 | Created by Aaron Springer and produced by Cartoon Network Studios. Animation was directed by Genndy Tartakovsky of. It premiered June 4, 2006. Two more storyboards were ordered, but the series was not greenlit due to financial reasons. Aired as daylight saving time filler during Toonami. |
| Let's Fish | 2007 | Created by Mark Rivers. Starring Scott Adsit and Brendon Small. Pilot rejected by Adult Swim. |
| The Lewis Lectures | 2002 | Created by Merrill Markoe and produced by Soup2Nuts. Starring Jack Black as a Tony Robbins-esque dog. Pilot rejected by Cartoon Network in 2000 and was not picked up by Adult Swim. |
| Macbeth with Dinosaurs | 2021 | Pilot uploaded to the Adult Swim's YouTube channel on September 9, 2021. Aired on Adult Swim on February 1, 2023. |
| The Mark Lembeck Technique | 2016 | Live action comedy starring Jason Alexander. Aired December 2, 2016. |
| Mystery Cuddlers | 2024 | Created by Pendleton Ward and Jack Pendarvis. It aired on November 19, 2024 at 4:00 am. Pilot was uploaded to the Adult Swim's YouTube channel on the same day. |
| Neon Knome | 2008 | Created by Ben Jones and produced by PFFR. Moved to Cartoon Network due to Adult Swim executives thinking it was too "mind-blowingly cute" for the block and reworked into The Problem Solverz, with Cartoon Network Studios and Mirari Films producing the series. |
| Ole Bud's ANU Football Weekly | 2018 | Aired on October 22, 2018. |
| Paid Programming | 2009 | The pilot aired as a "special" unannounced on November 3, 2009, then re-aired every Tuesday-Thursday until December 3, 2009. It was not picked up for a full series, as confirmed when creator, H. Jon Benjamin, called it an "abject failure". |
| Penguins Behind Bars | 2003 | Created by Janet Perlman and produced by Hulascope Studio. Aired once on July 20, 2003 and rejected by Adult Swim; did not receive acknowledgement until it was uploaded onto the Adult Swim website. |
| Pibby | 2021 | Created by Dodge Greenley and produced by Cartoon Network Studios. Concept trailer uploaded to the Adult Swim YouTube channel on October 30, 2021. The trailer received widespread popularity online and the concept would be expanded on during Adult Swim's April Fools 2022 broadcast. On October 3, 2023, Greenley announced Pibby would not be moving forward as a series. On April 26, 2024, Dodge Greenley uploaded parts of a storyboard for a Pibby pilot to his website, providing fans a glimpse into what had been developed. The storyboard was removed from the website the following day. The full animatic of the pilot was leaked online on June 30, 2024. |
| The Pound Hole | 2015 | 15 minute short set to introduce the pilot on April 20, 2015. |
| Saddle Rash | 2002 | Created by Loren Bouchard and produced by FlickerLab. It was rejected by Adult Swim. |
| Snake 'n' Bacon | 2009 | The pilot first aired May 10, 2009. It was entered in a Burger King popularity contest to be aired in March and then re-evaluated for a series run, but was not successful. |
| Southies | 2011 | Animated comedy about a family in South Boston. Created by Carl W. Adams who worked on Dr. Katz, Home Movies, and Assy McGee. Pilot aired in Adult Swim's "DVR theater" on January 19, 2011. |
| Stiff | 2007 | Live-action special from Matt Maiellaro, it aired on Adult Swim on October 31, 2007. |
| That Crook'd 'Sipp | 2007 | Created by Nick Weidenfeld, Jacob Escobedo, and Mike Weiss and starring David Banner. Pilot aired on May 13, 2007. The show idea was scrapped and later produced into the hour-long special Freaknik: The Musical, which first aired on March 7, 2010. |
| Totally for Teens | 2011 | Pilot from Derrick Beckles and Sabrina Saccoccio, and executively produced by Vernon Chatman, and Ari Fishman from The Daily Show. Pilot aired in Adult Swim's "DVR theater" on January 20, 2011. |
| Trap Universe | 2018 | Created by JJ Villard, who created King Star King and later JJ Villard's Fairy Tales, and produced by Titmouse, Inc. for Adult Swim. Aired on May 13, 2018. |
| Übermansion | 2013 | Animated pilot by Zeb Wells and Matthew Senreich. Produced by Stoopid Buddy Stoodios and Stoop!d Monkey. The pilot was released online on July 22, 2013, as part of a vote to decide whether or not it will air on August 26. The pilot won and aired on television on August 26, 2013. Later picked up by online service Crackle and retitled SuperMansion. |
| Welcome to Eltingville | 2002 | Created by Evan Dorkin and produced by Cartoon Network Studios. An adaptation of Dorkin's Eisner Award-winning comic book Dork!. |
| Yenor | 2023 | Created by Matt Maiellaro. Aired on February 1, 2023. |