Docosatetraenoic acid

• all-cis-7,10,13,16-docosatetraenoic acid is an omega-6 [fatty acid|ω-6 fatty acid] with the common name adrenic acid. This is a naturally occurring polyunsaturated fatty acid formed through a 2-carbon chain elongation of arachidonic acid. It is one of the most abundant fatty acids in the early human brain. This unsaturated fatty acid is also metabolized by cells to biologically active products viz., dihomoprostaglandins, and epoxydocosatrienoic acids. In addition to being endothelium-derived hyperpolarizing factors, EDTs have demonstrated anti-endoplasmic reticulum stress and anti-nociceptive activities. They are hydrolyzed by the soluble [epoxide hydrolase] to dihydroxydocosatrienoic acids and hence might play a role in the efficacy of sEH inhibitors.