Adafenoxate
Adafenoxate is a compound related to centrophenoxine, that has been found to act as a nootropic in rats.
Synthesis
Adafenoxate can be prepared starting with 4-chlorophenoxyacetic acid by converting it to its acid chloride to give 4-chlorophenoxyacetyl chloride. Esterification with 2-ethanol gives adafenoxate.Alternatives, the final step can be accomplished via Fischer–Speier esterification using a Dean-Stark trap.