Dyschromatosis symmetrica hereditaria

Dyschromatosis symmetrica hereditaria is a rare autosomally inherited dermatosis. It is characterized by progressively pigmented and depigmented macules, often mixed in a reticulate pattern, concentrated on the dorsal extremities. It was first reported in Japan, but has also been found to affect individuals from Europe, India and the Caribbean.

Genetics

This disease is caused by mutation in the double stranded RNA specific adenosine deaminase gene. This gene is located on the long arm of chromosome 1.

Diagnosis

Diagnosis is by visualisation and skin biopsy.