Acetylcysteinamide

N-Acetylcysteine amide is an amide derivative of N-acetylcysteine that appears to have better blood–brain barrier permeability and bioavailability possessing potential antioxidant and anti-inflammatory activity
When administered, N-acetylcysteine amide increases glutathione levels. Glutathione neutralizes reactive oxygen species, reduces oxidative stress, and prevents induced cell damage and apoptosis. NACA has increased lipophilicity and membrane permeability compared to NAC.

chemical designation

This compound belongs to a class of experimental compounds known as n-acyl-alpha-amino acids and their derivatives. These are compounds containing an alpha-amino acid with an acyl group on the terminal nitrogen atom.

pharmacokinetics and pharmacodynamics

The pharmacokinetics of N-Acetylcysteine amide remain unclear or unstudied.
N-acetylcysteineamide is an amide derivative of N-acetylcysteine that is rapidly converted to NAC after systemic administration.
The bioavailability of NACA is significantly higher than NAC.
Its mechanism of action involves replenishment of GSH, a major antioxidant, and direct neutralization of reactive oxygen species.