Acetyl-CoA carboxytransferase

Acety-CoA carboxytransferase is a transferase enzyme that catalyses the transfer of a carboxyl group from a biotinylated biotin carboxyl carrier protein to acetyl-CoA, yielding malonyl-CoA. In some species, this is part of a multi-domain protein that also has the carrier protein as well as biotin carboxylase. Some enzymes can also carry out the carboxylation of propanonyl-CoA and butanoyl-CoA. The enzyme catalyzes the following reaction,
The enzyme is involved in several biochemical pathways, including the 3-hydroxypropanoate cycle, 4-hydroxybutanate cycle, the assembly of biotin-carboxyl carrier proteins, candicidin biosynthesis, fatty acid biosynthesis and glyoxylate assimilation.