Acacius II of Melitene
Acacius II of Melitene was metropolitan bishop of Melitene. He was an opponent of Nestorius and close ally of Cyril of Alexandria at the Council of Ephesus of 431. He delivered a homily at Ephesus and wrote two letters to Cyril. Cyril in turn wrote two letters to Acacius. Melitene was a town in Eastern Anatolia.
His successor was Constantine of Melitene. He would have been a young bishop at the time of the Second Council of Ephesus.