A chromatin integration labelling method enables epigenomic profiling with lower input
A chromatin integration labelling method enables epigenomic profiling with lower input is a scholarly work by Tetsuya Handa, Yasuhiro Arimura, Katsuhiko Shirahige, Hitoshi Kurumizaka, Hiroshi Kimura, and Yasuyuki Ohkawa, published in 2018 in ''Nature Cell Biology''. The main subjects of the publication include chromatin immunoprecipitation, genomic DNA, ChIP on chip, CRISPR, biology, epigenetics, chromatin, cell biology, computational biology, immunoprecipitation, molecular biology, ChIP-sequencing, DNA methylation, histone, epigenomics, deoxyribonucleic acid, and genetics. The authors established an immunoprecipitation-free epigenomic profiling method named chromatin integration labelling (ChIL), which enables the amplification of genomic sequences closely associated with the target molecules before cell lysis.