AW-15'1129

AW-15'1129 is a drug with an imidazo-quinazoline based structure. The pharmacology is described as antidepressant based on strong adrenergic and anti-REM effects. It was invented by Othmar Dr Schindler of Wander AG in the 1960's. Although the drug is not known to have ever been commercialized, it is a representative example of a psychochemical based on a rational synthetic design.
In the patent the dosage of API is formulated to a strength of 4mg per tablet.

Synthesis

2-aminobenzonitrile is reacted with ethylenediamine to give the cyclic aminal.
This is then refluxed with benzaldehyde in alcoholic acid to give 6-phenyl-2,3,6,7-tetrahydro-4H-pyrimidoquinazoline.