ARHGAP5Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.FunctionRho GTPase-activating protein 5 negatively regulates RHO GTPases, a family of proteins that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.InteractionsARHGAP5 has been shown to interact with Rnd1, Rnd2, Rnd3 and RHOA.