ARF3ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.FunctionADP-ribosylation factor 3 is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns.InteractionsARF3 has been shown to interact with: ARFIP1, ARFIP2, GGA1, GGA3, and KIF23.