Annexin A3

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.
It is abnormally expressed in fetuses of both in [vitro fertilization|IVF] and intracytoplasmic [sperm injection|ICSI], which may contribute to the increase risk of birth defects in these assisted [reproductive technology|ART].
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.