ANO3

ANO3 is a gene that in humans is located on chromosome 11 and encodes the protein anoctamin 3. It belongs to a family of genes that appear to encode calcium-activated chloride channels.

Clinical significance

Mutations in ANO3 have been linked to a form of autosomal dominant cranio-cervical dystonia, which presents as abnormal twisting or tremulous movements of the face, voice, head and upper limbs.