Α-Ethylmescalineα-Ethylmescaline is a chemical compound of the phenethylamine family related to the psychedelic drug mescaline.Use and effectsIn his book PiHKAL, Alexander Shulgin lists AEM's dose as greater than 220mg orally and its duration as unknown. It was found to be completely inactive in terms of both central and peripheral effects in humans.ChemistryDerivativesAlexander Shulgin never synthesized further α position-extended mescaline analogues, such as α-propylmescaline or α-butylmescaline, as the inactivity of AEM in humans discouraged him. In any case, APM and ABM have been found to be inactive in terms of induction of the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and hence may be non-hallucinogenic in humans as well.HistoryAEM was first described in the scientific literature by Alexander Shulgin by 1963. He tested it and found it to be inactive in 1961. Later, Shulgin described AEM in greater detail in his 1991 book PiHKAL.