Adenosine diphosphate ribose

Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose by the CD38 enzyme using nicotinamide adenine dinucleotide as a cofactor.
ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 channel. cADPR also binds to TPRM2, and the action of both molecules is synergistic, with both molecules enhancing the action of the other molecule in activating the TRPM2 channel. Researchers are not sure how the Adenosine diphosphate reacts with the TRPM2 channel, but the ribose sugar may play a role in activating the TRPM2 ion channel.
Researchers believe that co-targeting DNA-dependent protein kinase and poly polymerase-1 does not promote apoptosis or mitotic catastrophe of cancer cells after radiation.