AD-mix
In organic chemistry, AD-mix is a commercially available mixture of reagents that acts as an asymmetric catalyst for various chemical reactions, including the Sharpless asymmetric dihydroxylation of alkenes. The two letters AD, stand for asymmetric dihydroxylation. The mix is available in two variations, "AD-mix α" and "AD-mix β" following ingredient lists published by Barry Sharpless.
The mixes contain:
- Potassium osmate K2OsO24 as the source of Osmium tetroxide
- Potassium ferricyanide K3Fe6, which is the re-oxidant in the catalytic cycle
- Potassium carbonate
- A chiral ligand:
- *AD-mix α contains 2PHAL, the phthalazine adduct with dihydroquinine