A roads in Zone 5 of the Great Britain numbering scheme
List of A roads in zone 5 in Great Britain starting north/east of the A5, west of the A6, south of the Solway Firth/Eden Estuary.
Single- and double-digit roads
| Road | From | To | Notes |
| Central London | Holyhead | Forms parts of the historical route of Watling Street. The section from M1 J4 north of Edgware to N. of Dunstable is now numbered A5183. The A5 now starts at M1 J11A and runs west to join previous alignment. | |
| Leicester | Warrington | Becomes M1 motorway between junctions 22 and 24A. Used to start at Hockliffe on A5, north of Dunstable. Gradually cut back to Northampton, then Leicester. Before opening of Derby southern bypass in 1997, it followed present A511 between Markfield and Foston. Also used as a provisional number for the London-Yorkshire motorway that eventually became the M1. | |
| Chester | Kingsbury | Formerly ending at the A5 in Tamworth, the road to the south was the northern end of the A423. When the latter was downgraded north of Coventry, the A51 was extended to the A47. Subsequently, the A47 too was downgraded and the A51 was then cut back to its present terminus near Kingsbury. | |
| Newcastle-under-Lyme | Mablethorpe | ||
| Buxton | Shrewsbury | ||
| Tarvin | Buxton | The section between Congleton and Buxton is the most dangerous road in Britain. | |
| Holyhead | Chester | Also known as the "North Wales Expressway". | |
| Chester | A59 near Broughton | ||
| Liverpool | Lincoln | ||
| Prescot | Wetherby | Becomes A58 as part of Leeds Inner Ring Road | |
| Wallasey | York |