5-MeO-NBpBrT
5-MeO-NBpBrT, also known as 5-methoxy-N-tryptamine, is an N-substituted member of the 5-methoxytryptamine family of compounds. Like other such compounds, it acts as an antagonist for the serotonin 5-HT2A receptor, with a claimed 100-fold selectivity over the closely related serotonin 5-HT2C receptor. While N-benzyl substitution of psychedelic phenethylamines often results in potent serotonin 5-HT2A agonists, it had been thought that N-benzyltryptamines show much lower efficacy and are either very weak partial agonists or antagonists at the serotonin 5-HT2A receptor, though more recent research has shown stronger agonist activity for 3-substituted benzyl derivatives. Extending the benzyl group to a substituted phenethyl can also recover agonist activity in certain cases.