4-PhPr-2,5-DMA

4--2,5-dimethoxyamphetamine, also known as 4-PhPr-2,5-DMA, is a serotonin receptor modulator of the phenethylamine, amphetamine, and DOx families. It shows high affinity for both the serotonin 5-HT_2A and 5-HT_2C receptors and acts as a weak partial agonist or antagonist of the serotonin 5-HT_2A receptor. The drug has lower affinity for the serotonin 5-HT_2A receptor than its closely related positional isomer 4-PhPr-3,5-DMA. This is an apparent reversal of the usual situation with DOx and related drugs in which the 2,5-dimethoxy pattern is optimal for serotonin 5-HT_2A receptor interactions.