4-HO-MiPT
4-HO-MiPT, also known as 4-hydroxy-N-methyl-N-isopropyltryptamine or as miprocin, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to psilocin. It appears to be similar to psilocin in terms of onset, duration, and effects. The drug is taken orally.
It acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor among others. The drug is closely related structurally to MiPT, 4-HO-DiPT, and psilocin.
4-HO-MiPT was first described in the literature by David Repke and colleagues in 1981. Its effects in humans were subsequently described by Repke and Alexander Shulgin in 1985 and 1997.
Use and effects
According to Alexander Shulgin in his book TiHKAL and other publications, 4-HO-MiPT has a dose range of 12 to 25mg, an onset of action of 10 to 20minutes, a time to peak of 40 to 45minutes, and a duration of 4 to 6hours. It has an estimated typical dose of 18.5mg. The drug has been described as at least twice as potent as psilocin at comparable doses, with 20mg 4-HO-MiPT being subjectively stronger than 50mg psilocin in one individual. However, in another person, the effects of 4-AcO-MiPT at a dose of 30mg were described as considerably more modest than expected.The effects of 4-HO-MiPT have been reported to include closed-eye visuals, vivid mental imagery, few psychedelic visuals, wave-form visuals, intense color alterations, multiple images of the same object with intense colored halos, illusory alteration of the size and distance of objects, heightening of senses, intensification and enhanced discrimination of sounds, increased sense of bodily processes such as blood flow and muscles, synesthesia of sound and sight, intense alteration in sense of time and distance, feelings of drifting in and out of the body, flight of ideas, philosophical thinking, euphoria, enhanced music appreciation, enhanced eroticism, and facilitation of love, insights, fantasy, introspection, and discovery. Other effects included intoxication, sedation, feeling drunk, relaxation, some initial anxiety, easy to difficult verbal communication, easy distraction and annoyance by external stimuli such as light, appetite loss, and insomnia. Physical effects of the drug have been reported to include twitching, muscle sensations, motor incoordination, slight lightheadedness, mild vertigo, jaw clenching, and body tremors.
Interactions
Pharmacology
Pharmacodynamics
4-HO-MiPT acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. It shows the highest potency and efficacy as an agonist of the 5-HT2A receptor, moderate potency as a partial agonist of the 5-HT2B receptor, and low potency with high-efficacy as a partial agonist of the 5-HT2C receptor. Additionally, the drug has been found to act as a moderate-potency serotonin transporter blocker or serotonin reuptake inhibitor. Its low affinity and potency at the 5-HT1A receptor suggest minimal contribution to this drug's effects. 4-HO-MiPT exhibits approximately 7-fold selectivity for activation of the serotonin 5-HT2A receptor over the serotonin 5-HT2C receptor, and 4-fold preference relative to SERT inhibition. Affinities towards receptors outside of the serotonin receptor family have not yet been assessed.The drug induces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. Its potency for inducing the head-twitch response in mice is about 4- or 5-fold lower than that of psilocin.