3-Methoxymethcathinone
3-Methoxymethcathinone, also known as meta-methoxymethcathinone, is a designer drug of the substituted cathinone family described as a stimulant.
Similarly to other cathinones, it acts as a monoamine releasing agent, including of serotonin, dopamine, and norepinephrine. However, in contrast to cathinones and amphetamines, 3-MeOMC appears to show selectivity for induction of serotonin and dopamine release over release of norepinephrine, and hence may act as a partially selective serotonin–dopamine releasing agent. Its values are 129nM for dopamine release and 306nM for serotonin release in vitro, whereas it only induced 68% release of norepinephrine at a concentration of 10μM. For comparison, other related cathinones, including cathinone, methcathinone, 3-methylmethcathinone, 4-methylmethcathinone, and 4-methoxymethcathinone, induced 94 to 101% release of norepinephrine at 10μM. However, in another publication, the of 3-MeOMC for induction of norepinephrine release was 111nM, and hence it did not appear to show selectivity for induction of serotonin and dopamine release relative to norepinephrine, instead acting as a serotonin–norepinephrine–dopamine releasing agent.
3-MeOMC first appeared as an illicit drug after 2014.