3-Thiomescaline

3-Thiomescaline, also known as 3-methylthio-4,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline. It is the analogue of mescaline in which the methoxy group at the 3 position has been replaced with a methylthio group. The drug is one of two possible thiomescaline positional isomers, the other being 4-thiomescaline.
In his book PiHKAL and other publications, Alexander Shulgin lists 3-TM's dose as 60 to 100mg orally and its duration as 8 to 12hours. Its onset is within 1hour. The drug has about 4 to 6times the potency of mescaline. The effects of 3-TM have been reported to include color enhancement, closed-eye imagery and fantasy, no open-eye visuals, auditory–visual synaesthesia with music, intoxication, relaxation, feelings of sublimity and peacefulness, conflicting energy, tension, paranoia, irritability, and guardedness.
The chemical synthesis of 3-TM has been described.
3-TM was first described in the literature by Shulgin and colleagues by 1981. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.