3-Isopropylmalate dehydrogenase
3-Isopropylmalate dehydrogenase is an enzyme that is a part of the isopropylmalate dehydrogenase family, which catalyzes the overall chemical reaction:
The first step is an oxidation reaction in which the cofactor, oxidised nicotinamide adenine dinucleotide, converts the hydroxy group of the malic acid derivative into the corresponding keto group. This spontaneously decarboxylates to give the observed product.