3-Chloroamphetamine

3-Chloroamphetamine, also known as meta-chloroamphetamine, is a psychostimulant of the amphetamine family and a serotonergic neurotoxin related to para-chloroamphetamine.
The drug is a potent serotonin–norepinephrine–dopamine releasing agent. Its values for induction of monoamine release are 9.4nM for norepinephrine, 11.8nM for dopamine, and 120nM for serotonin. Hence, 3-CA shows around 10-fold preference for induction of catecholamine release over induction of serotonin release.
3-CA is closely related to the potent serotonergic neurotoxin PCA. In contrast to PCA, 3-CA produced no serotonergic neurotoxicity in rodents. However, this was found to be due to rapid metabolism via para-hydroxylation. When the metabolism of 3-CA was inhibited, the drug produced approximately equivalent serotonergic neurotoxicity to PCA.