25O-NBOMe

25O-NBOMe, also known as 2,4,5-TMPEA-NBOMe or as N--2,4,5-trimethoxyphenethylamine, is a serotonin [receptor modulator] and putative psychedelic drug of the phenethylamine and 25-NB families. It is the N- derivative of 2C-O.
The drug is known to act as a serotonin 5-HT_2A receptor partial agonist, with an of 1.02 to 7.24nM and an of 57 to 129%. It activated the serotonin 5-HT_2A receptor with 191- to 309-fold higher potency than 2C-O in vitro. 25O-NBOMe robustly and dose-dependently induces the head-twitch response, a behavioral proxy of psychedelic effects, in mice, with an of 0.70mg/kg. For comparison, in other studies in mice, the of 25I-NBOMe was 0.078mg/kg and of 25D-NBOMe was 0.23mg/kg.
25O-NBOMe was first described in the scientific literature by 2009. It is a controlled substance in Canada under phenethylamine blanket-ban language.