22R-Hydroxycholesterol
22R-Hydroxycholesterol, or -cholest-5-ene-3,22-diol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Cholesterol is hydroxylated by cholesterol side-chain cleavage enzyme to form 22R-hydroxycholesterol, which is subsequently hydroxylated again by P450scc to form 20α,22R-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone, the precursor to the steroid hormones.
It is an agonist of the liver X receptor.