2025 Mutua Madrid Open – Men's singles
Casper Ruud defeated Jack Draper in the final, 7–5, 3–6, 6–4 to win the men's singles tennis title at the 2025 Madrid Open. By winning his first ATP 1000 title, he became the first Norwegian champion in Masters series history. Aged 23 years and 121 days old, Draper was the youngest British man in the Open Era to reach ATP Tour finals on clay, grass and hardcourt.
Andrey Rublev was the defending champion, but lost in the third round to Alexander Bublik. Aged 38 years and 7 months old, Gaël Monfils became the oldest man to win a singles main draw match in tournament history.
Seeds
All seeds received a bye into the second round.Draw
Finals
Seeded players
The following are the seeded players. Seedings are based on ATP rankings as of 21 April 2025. Rankings and points before are as of 21 April 2025.| Seed | Rank | Player | Points before | Points defending | Points earned | Points after | Status | |||
| 1 | 2 |  Withdrawn seeded playersThe following player would have been seeded, but withdrew before the tournament began.
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